Mitchell Moffit and Gregory Brown of AsapSCIENCE thoroughly explain why sitting for extended periods of time—at a desk at work, for example—can be harmful to one’s health. Possible adverse effects include decreased bone mass, muscle weakening, increased LDL cholesterol, and even a shortened lifespan and for sure has negative impact on your running. I started standing at my desk while working, and the video they made is great..... video describing ways to solve the sitting problem
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